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Article

The Insulin-Like Factor 3 (INSL3)-Receptor (RXFP2) Network Functions as a Germ Cell Survival/Anti-Apoptotic Factor in Boar Testes

6 Jan 2015

Abstract excerpt

Relaxin-like factor, commonly known as insulin-like factor (INSL3), is essential for testis descent during fetal development; however, its function in the adult testis is still being elucidated. The study aimed to identify a relaxin family peptide receptor 2 (RXFP2)-specific antibody suitable for immunological approaches, analyze which testicular germ cell types express RXFP2, and clarify its expression dynamics...

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PMID: 25562614
DOI: 10.1210/en.2014-1473

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Related research

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The Insulin-Like Factor 3 (INSL3)-Receptor (RXFP2) Network Functions as a Germ Cell Survival/Anti-Apoptotic Factor in Boar TestesPMID 25562614Read ↗

Evidence for the role of INSL3 on sperm production in boars by passive immunisationSemantic proximity Read ↗

Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiologySemantic proximity Read ↗

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Relaxin family peptides in the male reproductive system--a critical appraisalSemantic proximity Read ↗

Rln3a is a prerequisite for spermatogenesis and fertility in male fish.Semantic proximity Read ↗

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.Semantic proximity Read ↗

Relaxin‐like peptides in male reproduction – a human perspectiveSemantic proximity Read ↗

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs1Semantic proximity Read ↗

Cellular Distribution of Transforming Growth Factor Betas 1, 2, and 3 and their Types I and II Receptors during Postnatal Development and Spermatogenesis in the Boar Testis1Semantic proximity Read ↗

INSL3 stimulates spermatogonial differentiation in testis of adult zebrafish (Danio rerio)Semantic proximity Read ↗

Identification of INSL6, a New Member of the Insulin Family That Is Expressed in the Testis of the Human and Rat1Semantic proximity Read ↗

Bi-allelic variants inINSL3andRXFP2cause bilateral cryptorchidism and male infertilitySemantic proximity Read ↗

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