Article
Myeloproliferative neoplasms with concurrent BCR-ABL1 translocation and JAK2 V617F mutation: a multi-institutional study from the bone marrow pathology group.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2018
Soderquist Craig R, Ewalt Mark D, Czuchlewski David R, Geyer Julia T, Rogers Heesun J, Hsi Eric D, Wang Sa A, Bueso-Ramos Carlos E, Orazi Attilio, Arber Daniel A, Hexner Elizabeth O, Babushok Daria V, Bagg Adam
Abstract excerpt
Myeloproliferative neoplasms arise from hematopoietic stem cells with somatically altered tyrosine kinase signaling. Classification of myeloproliferative neoplasms is based on hematologic, histopathologic and molecular characteristics including the presence of the BCR-ABL1 and JAK2 V617F. Although thought to be mutually exclusive, a number of cases with co-occurring BCR-ABL1 and JAK2 V617F have been identified....
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