Article
Mixed-phenotype large granular lymphocytic leukemia: a rare subtype in the large granular lymphocytic leukemia spectrum.
Human pathology - 1 Nov 2018
Neff Jadee L, Rangan Aruna, Jevremovic Dragan, Nguyen Phuong L, Chiu April, Go Ronald S, Chen Dong, Morice William G, Shi Min
Abstract excerpt
Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which more than 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL and chronic lymphoproliferative disorder of natural killer (NK) cells. The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed...
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