Article
Assessment of prognostic implication of a panel of oncogenes in bladder cancer and identification of a 3-gene signature associated with recurrence and progression risk in non-muscle-invasive bladder cancer.
Scientific reports - 6 Oct 2020
Le Goux Constance, Vacher Sophie, Schnitzler Anne, Barry Delongchamps Nicolas, Zerbib Marc, Peyromaure Michael, Sibony Mathilde, Allory Yves, Bieche Ivan, Damotte Diane, Pignot Geraldine
Abstract excerpt
This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prognostic markers. Mutations of HRAS, FGFR3, PIK3CA and TERT were found in 2.9%, 27.2%, 14.9% and...
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