Article
Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma.
European urology - 1 Dec 2020
Teo Min Yuen, Mota Jose Mauricio, Whiting Karissa A, Li Han A, Funt Samuel A, Lee Chung-Han, Solit David B, Al-Ahmadie Hikmat, Milowsky Matthew I, Balar Arjun V, Pietzak Eugene, Dalbagni Guido, Bochner Bernard H, Ostrovnaya Irina, Bajorin Dean F, Rosenberg Jonathan E, Iyer Gopa
Abstract excerpt
BACKGROUND: Alterations in fibroblast growth factor receptor 3 (FGFR3) occur in ∼15% of muscle-invasive bladder cancers (MIBCs) and metastatic urothelial carcinomas (mUCs). OBJECTIVE: To determine the association between FGFR3 status and response to platinum-based chemotherapy in patients with MIBC or mUC. DESIGN, SETTING, AND PARTICIPANTS: The authors conducted a retrospective review and comparison of patients...
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