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Article

Transforming Potential of the Herpesvirus Oncoprotein MEQ: Morphological Transformation, Serum-Independent Growth, and Inhibition of Apoptosis

1 Jan 1998

Abstract excerpt

Marek's disease virus (MDV) induces the rapid development of overwhelming T-cell lymphomas in chickens. One of its candidate oncogenes, meq (MDV Eco Q) which encodes a bZIP protein, has been biochemically characterized as a transcription factor. Interestingly, MEQ proteins are expressed not only in the nucleoplasm but also in the coiled bodies and the nucleolus. Its novel subcellular localization suggests that...

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Identifiers

PMID: 9420237
DOI: 10.1128/jvi.72.1.388-395.1998

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Related research

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Research trail→

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Transforming Potential of the Herpesvirus Oncoprotein MEQ: Morphological Transformation, Serum-Independent Growth, and Inhibition of ApoptosisPMID 9420237Read ↗

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncovirusesSemantic proximity Read ↗

Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replicationSemantic proximity Read ↗

Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease VirusSemantic proximity Read ↗

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus.Semantic proximity Read ↗

Marek’s disease virus: lytic replication, oncogenesis and controlSemantic proximity Read ↗

Integrated Analyses of Genome-Wide DNA Occupancy and Expression Profiling Identify Key Genes and Pathways Involved in Cellular Transformation by a Marek's Disease Virus Oncoprotein, MeqSemantic proximity Read ↗

Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in ChickensSemantic proximity Read ↗

Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQSemantic proximity Read ↗

Marek’s Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling PathwaysSemantic proximity Read ↗

Characterization of the Chromosomal Binding Sites andDimerization Partners of the Viral Oncoprotein Meq in Marek'sDisease Virus-Transformed TCellsSemantic proximity Read ↗

Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors.Semantic proximity Read ↗

Marek’s disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathwaySemantic proximity Read ↗

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