Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.

doi:10.1016/j.ccell.2018.05.012

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Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.

Cancer cell - 9 Jul 2018

Pavlyukov Marat S, Yu Hai, Bastola Soniya, Minata Mutsuko, Shender Victoria O, Lee Yeri, Zhang Suojun, Wang Jia, Komarova Svetlana, Wang Jun, Yamaguchi Shinobu, Alsheikh Heba Allah, Shi Junfeng, Chen Dongquan, Mohyeldin Ahmed, Kim Sung-Hak, Shin Yong Jae, Anufrieva Ksenia, Evtushenko Evgeniy G, Antipova Nadezhda V, Arapidi Georgij P, Govorun Vadim, Pestov Nikolay B, Shakhparonov Mikhail I, Lee L James, Nam Do-Hyun, Nakano Ichiro

Abstract excerpt

Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic and surviving cancer cells remain elusive. In this study, we demonstrate that apoptotic GBM cells paradoxically promote proliferation and therapy resistance of surviving tumor cells by secreting apoptotic extracellular vesicles (apoEVs)...

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Identifiers

PMID: 29937354
DOI: 10.1016/j.ccell.2018.05.012
PMCID: PMC6048596

Genes

RBM11
MDM4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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