Article
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Stem cell reports - 6 Jun 2017
Godlewski Jakub, Ferrer-Luna Ruben, Rooj Arun K, Mineo Marco, Ricklefs Franz, Takeda Yuji S, Nowicki M Oskar, Salińska Elżbieta, Nakano Ichiro, Lee Hakho, Weissleder Ralph, Beroukhim Rameen, Chiocca E Antonio, Bronisz Agnieszka
Abstract excerpt
Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells...
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