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Article

Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice.

Journal of dental research - 1 Nov 2018

Wang H, Lv C, Gu Y, Li Q, Xie L, Zhang H, Miao D, Sun W

Abstract excerpt

Sirt1 promotes odontoblastic gene expression in human dental pulp cells, whereas the inhibition of Sirt1 downregulates the expression of those genes. To investigate whether the overexpression of Sirt1 in mesenchymal stem cells (MSCs) driven by Prx1 promoter could rescue the dentin formation defects in Bmi1-deficient (Bmi1-/-) mice, we established the MSCs overexpressing Sirt1 in Bmi1 knockout mice...

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Source

Identifiers

PMID: 29932801
DOI: 10.1177/0022034518781509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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