Article
Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2012
Napierala Dobrawa, Sun Yao, Maciejewska Izabela, Bertin Terry K, Dawson Brian, D'Souza Rena, Qin Chunlin, Lee Brendan
Abstract excerpt
Dentinogenesis imperfecta (DGI) is a hereditary defect of dentin, a calcified tissue that is the most abundant component of teeth. Most commonly, DGI is manifested as a part of osteogenesis imperfecta (OI) or the phenotype is restricted to dental findings only. In the latter case, DGI is caused by mutations in the DSPP gene, which codes for dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). Although these...
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