Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

doi:10.1038/s41590-018-0133-z

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Article

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

Nature immunology - 1 Jul 2018

Napolitani Giorgio, Kurupati Prathiba, Teng Karen Wei Weng, Gibani Malick M, Rei Margarida, Aulicino Anna, Preciado-Llanes Lorena, Wong Michael Thomas, Becht Etienne, Howson Lauren, de Haas Paola, Salio Mariolina, Blohmke Christoph J, Olsen Lars Rønn, Pinto David Miguel Susano, Scifo Laura, Jones Claire, Dobinson Hazel, Campbell Danielle, Juel Helene B, Thomaides-Brears Helena, Pickard Derek, Bumann Dirk, Baker Stephen, Dougan Gordon, Simmons Alison, Gordon Melita A, Newell Evan William, Pollard Andrew J, Cerundolo Vincenzo

Abstract excerpt

To tackle the complexity of cross-reactive and pathogen-specific T cell responses against related Salmonella serovars, we used mass cytometry, unbiased single-cell cloning, live fluorescence barcoding, and T cell-receptor sequencing to reconstruct the Salmonella-specific repertoire of circulating effector CD4+ T cells, isolated from volunteers challenged with Salmonella enterica serovar Typhi (S. Typhi) or...

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PMID: 29925993
DOI: 10.1038/s41590-018-0133-z

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