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Article

The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles.

Immunology - 1 Nov 2014

Reynolds Catherine J, Jones Claire, Blohmke Christoph J, Darton Thomas C, Goudet Amelie, Sergeant Ruhena, Maillere Bernard, Pollard Andrew J, Altmann Daniel M, Boyton Rosemary J

Abstract excerpt

Detailed characterization of the protective T-cell response in salmonellosis is a pressing unmet need in light of the global burden of human Salmonella infections and the likely contribution of CD4 T cells to immunity against this intracellular infection. In previous studies screening patient sera against antigen arrays, SseB was noteworthy as a serodominant target of adaptive immunity, inducing significantly...

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Share to Antigen Presentation
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Epitopes, T-Lymphocyte

Share to Histocompatibility Antigens Class II

Share to HLA-DR Antigens

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Source

Open in PubMed Open full text

Identifiers

PMID: 24891088
DOI: 10.1111/imm.12327
PMCID: PMC4212957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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