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Article

Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer.

The pharmacogenomics journal - 1 Sept 2018

Suenaga Mitsukuni, Schirripa Marta, Cao Shu, Zhang Wu, Yang Dongyun, Cremolini Chiara, Lonardi Sara, Bergamo Francesca, Ning Yang, Yamamoto Noriko, Okazaki Satoshi, Berger Martin D, Miyamoto Yuji, Gopez Roel, Barzi Afsaneh, Yamaguchi Toshiharu, Stintzing Sebastian, Heinemann Volker, Loupakis Fotios, Falcone Alfredo, Lenz Heinz-Josef

Abstract excerpt

PIN1-mediated substrate isomerization plays a role in the repair of DNA double-strand breaks. We hypothesized that genetic polymorphisms in PIN1-related pathways may affect tumor sensitivity to oxaliplatin or irinotecan in metastatic colorectal cancer (mCRC) patients. We analyzed genomic DNA from five cohorts of mCRC patients (total 950) treated with different first-line treatments: oxaliplatin cohorts 1...

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Identifiers

PMID: 29925895
DOI: 10.1038/s41397-018-0030-8
PMCID: PMC6151284

Genes

PIN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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