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Article

Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer.

Cancer chemotherapy and pharmacology - 1 Jun 2013

Cortejoso Lucía, García María I, García-Alfonso Pilar, González-Haba Eva, Escolar Fernando, Sanjurjo María, López-Fernández Luis A

Abstract excerpt

PURPOSE: Oxaliplatin or irinotecan is usually administered jointly with fluoropyrimidines in colorectal cancer patients treated with chemotherapy. Both drugs have different toxicity patterns. Biomarkers for predicting high-risk severe adverse reactions can help select the best treatment. METHODS: A retrospective analysis of 106 colorectal cancer patients receiving an oxaliplatin-based treatment and 56 receiving...

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Source

Identifiers

PMID: 23543295
DOI: 10.1007/s00280-013-2145-6

Genes

ABCB1
ERCC1
GSTT1
ERCC2
GSTP1
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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