Article
Immunogenic cell death pathway polymorphisms for predicting oxaliplatin efficacy in metastatic colorectal cancer.
Journal for immunotherapy of cancer - 1 Nov 2020
Arai Hiroyuki, Xiao Yi, Loupakis Fotios, Kawanishi Natsuko, Wang Jingyuan, Battaglin Francesca, Soni Shivani, Zhang Wu, Mancao Christoph, Salhia Bodour, Mumenthaler Shannon M, Weisenberger Daniel J, Liang Gangning, Cremolini Chiara, Falcone Alfredo, Millstein Joshua, Lenz Heinz-Josef
Abstract excerpt
BACKGROUND: Immunogenic cell death (ICD) is a tumor cell death involving both innate and adaptive immune responses. Given published findings that oxaliplatin, but not irinotecan, drives ICD, we investigated whether single nucleotide polymorphisms (SNPs) in the ICD pathway are associated with the efficacy of oxaliplatin-based chemotherapy in metastatic colorectal cancer (mCRC). METHODS: Two randomized clinical...
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