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Article

Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.

PloS one - 1 Jan 2015

Plog Stephanie, Klymiuk Nikolai, Binder Stefanie, Van Hook Matthew J, Thoreson Wallace B, Gruber Achim D, Mundhenk Lars

Abstract excerpt

The human CLCA4 (chloride channel regulator, calcium-activated) modulates the intestinal phenotype of cystic fibrosis (CF) patients via an as yet unknown pathway. With the generation of new porcine CF models, species-specific differences between human modifiers of CF and their porcine orthologs are considered critical for the translation of experimental data. Specifically, the porcine ortholog to the human CF...

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Topics

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Share to Chloride Channels
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Electrophysiology

Share to Epithelial Cells

Share to Intestinal Mucosa

Share to Intestines

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Source

Open in PubMed Open full text

Identifiers

PMID: 26474299
DOI: 10.1371/journal.pone.0140050
PMCID: PMC4608703

Genes

CLCA4
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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