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Article

SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

13 Jul 2018

Abstract excerpt

The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the patient population and this variability is partially conferred by the influence of modifier genes. Genome-wide association studies have identified SLC6A14, an electrogenic amino acid transporter, as a genetic modifier of CF-associated meconium ileus. The purpose of the current work was to determine the biological role of...

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PMID: 30004386
DOI: 10.7554/elife.37963

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