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Article

Implication of critical pharmacokinetic gene variants on therapeutic response to metformin in Type 2 diabetes.

Pharmacogenomics - 1 Jul 2018

Phani Nagaraja M, Vohra Manik, Kakar Ananth, Adhikari Prabha, Nagri Shivashankara K, D'Souza Sydney C, Umakanth Shashikiran, Satyamoorthy Kapaettu, Rai Padmalatha S

Abstract excerpt

AIM: Metformin, an oral hypoglycemic drug is the first line of treatment for Type 2 diabetes individuals. We studied the effect of critical gene single nucleotide polymorphisms on the glucose lowering effect of metformin. METHOD: We performed a prospective study on 221 newly diagnosed, treatment-naive Type 2 diabetes subjects. Individuals were started with metformin monotherapy and followed up for 12 weeks....

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Share to Diabetes Mellitus, Type 2
Share to Glycated Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoglycemic Agents

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Share to Organic Cation Transport Proteins

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 29914345
DOI: 10.2217/pgs-2018-0041

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