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Article

Prolactin levels: sex differences in the effects of risperidone, 9-hydroxyrisperidone levels, CYP2D6 and ABCB1 variants.

Pharmacogenomics - 1 Jul 2018

Schoretsanitis Georgios, de Leon Jose, Diaz Francisco J

Abstract excerpt

AIM: The role of sex on the association of plasma prolactin levels with risperidone (R) and 9-hydroxyrisperidone (9-OHR) concentrations is investigated. METHODS: Plasma R and prolactin concentrations, CYP2D6 and exon 21 and 26 ABCB1 gene variants were studied in 110 patients. RESULTS: In females, a 1 ng/ml increase in R levels was associated with a significant 1.02% increase in prolactin levels. In males, a...

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Identifiers

PMID: 29914302
DOI: 10.2217/pgs-2018-0053

Genes

ABCB1

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