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Article

Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells.

Journal of cellular and molecular medicine - 1 Sept 2018

Vageli Dimitra P, Doukas Sotirios G, Spock Todd, Sasaki Clarence T

Abstract excerpt

The presence of bile is not an uncommon finding in acidic oesophageal and extra-oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF-κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that...

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Identifiers

PMID: 29911313
DOI: 10.1111/jcmm.13701
PMCID: PMC6111812

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EGFR
REL
RELA
STAT3
TNF

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