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Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

31 Jan 2024

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is associated with high mortality rates. Bile acids (BAs) reflux is a well-known risk factor for GC, but the specific mechanism remains unclear. During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming. This confers additional cancer phenotypes, including ferroptosis sensitivity. Ferroptosis is a novel mode of cell death...

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PMID: 38414591
DOI: 10.3748/wjg.v30.i5.485

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