Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells.

BMC molecular biology - 31 Jan 2012

Li Juan, Wang Kai, Chen Xuedan, Meng Hui, Song Min, Wang Yan, Xu Xueqing, Bai Yun

Abstract excerpt

BACKGROUND: miR-34a functions as an important tumor suppressor during the process of carcinogenesis. However, the mechanism of miR-34a dysregulation in human malignancies has not been well elucidated. Our study aimed to further investigate the regulation mechanism of miR-34a. RESULTS: We found that overexpression of NF-kappa B p65 subunit could increase miR-34a levels in EC109, an esophageal squamous cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Esophageal Neoplasms
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to NF-kappa B

Share to Transcription Factor RelA

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 22292433
DOI: 10.1186/1471-2199-13-4
PMCID: PMC3311059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells.PMID 22292433Read ↗

Nuclear Factor κB Signaling and Its Related Non-coding RNAs in Cancer TherapySemantic proximity Read ↗

miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesisSemantic proximity Read ↗

Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell CarcinomaSemantic proximity Read ↗

Contributions of NFKB1 -94insertion/deletion ATTG polymorphism to the susceptibility of gastrointestinal cancers: A meta-analysis.Semantic proximity Read ↗

MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback LoopSemantic proximity Read ↗

Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal CellsSemantic proximity Read ↗

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cellsSemantic proximity Read ↗

A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer CellsSemantic proximity Read ↗

miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling.Semantic proximity Read ↗

miR-29c-3p Increases Cell Viability and Suppresses Apoptosis by Regulating the TNFAIP1/NF-κB Signaling Pathway via TNFAIP1 in Aβ-Treated Neuroblastoma CellsSemantic proximity Read ↗

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.Semantic proximity Read ↗

Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.