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[18F]FMPEP-d2 PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease.

Neurobiology of aging - 1 Sept 2018

Takkinen Jatta S, López-Picón Francisco R, Kirjavainen Anna K, Pihlaja Rea, Snellman Anniina, Ishizu Tamiko, Löyttyniemi Eliisa, Solin Olof, Rinne Juha O, Haaparanta-Solin Merja

Abstract excerpt

Contradictory findings on the role of the type 1 cannabinoid receptor (CB1R) during the pathogenesis of Alzheimer's disease (AD) have been reported. Here, we evaluated the CB1R brain profile in an AD mouse model using longitudinal positron emission tomography with an inverse agonist for CB1R, [18F]FMPEP-d2. APP/PS1-21 and wild-type (n = 8 in each group) mice were repeatedly imaged between 6 to 15 months of age,...

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PMID: 29909177
DOI: 10.1016/j.neurobiolaging.2018.05.013

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APP

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