Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.

Neurobiology of aging - 1 Nov 2013

Stumm Christoph, Hiebel Christof, Hanstein Regina, Purrio Martin, Nagel Heike, Conrad Andrea, Lutz Beat, Behl Christian, Clement Angela B

Abstract excerpt

Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition. Here, we studied the impact of cannab...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Weight

Share to Cognition Disorders

Share to Maze Learning

Share to Microglia

Share to Peptide Fragments

Share to Receptor, Cannabinoid, CB1

Source

Identifiers

PMID: 23838176
DOI: 10.1016/j.neurobiolaging.2013.05.027

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23838176-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.PMID 23838176Read ↗

Early alteration of distribution and activity of hippocampal type-1 cannabinoid receptor in Alzheimer's disease-like mice overexpressing the human mutant amyloid precursor protein.Semantic proximity Read ↗

Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal modelSemantic proximity Read ↗

APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS DisorderSemantic proximity Read ↗

An enquiry to the role of CB1 receptors in neurodegenerationSemantic proximity Read ↗

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.Semantic proximity Read ↗

Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse ModelSemantic proximity Read ↗

Cannabinoid Type 1 Receptor Antagonist Impaired Spatial Memory and Increased the Tau Gene Expression in Animal Model of the Alzheimer's diseaseSemantic proximity Read ↗

[18F]FMPEP-d2 PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s diseaseSemantic proximity Read ↗

Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice.Semantic proximity Read ↗

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.