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Article

Inhibitor-assisted refolding of protease: a protease inhibitor as an intramolecular chaperone.

FEBS letters - 15 Aug 2005

Kojima Shuichi, Iwahara Akane, Yanai Hideyuki

Abstract excerpt

Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and in vivo experiments. The specific cleavage between POIA1 and...

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Identifiers

PMID: 16061231
DOI: 10.1016/j.febslet.2005.06.083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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