Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.

doi:10.1152/ajpheart.00307.2014

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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2014

Csiszar Anna, Gautam Tripti, Sosnowska Danuta, Tarantini Stefano, Banki Eszter, Tucsek Zsuzsanna, Toth Peter, Losonczy Gyorgy, Koller Akos, Reglodi Dora, Giles Cory B, Wren Jonathan D, Sonntag William E, Ungvari Zoltan

Abstract excerpt

In rodents, moderate caloric restriction (CR) without malnutrition exerts significant cerebrovascular protective effects, improving cortical microvascular density and endothelium-dependent vasodilation, but the underlying cellular mechanisms remain elusive. To elucidate the persisting effects of CR on cerebromicrovascular endothelial cells (CMVECs), primary CMVECs were isolated from young (3 mo old) and aged (24...

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PMID: 24906921
DOI: 10.1152/ajpheart.00307.2014
PMCID: PMC4121647

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