Article
Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice.
Brain research - 15 Oct 2018
Matagne Valerie, Wondolowski Joyce, Frerking Matthew, Shahidullah Mohammad, Delamere Nicholas A, Sandau Ursula S, Budden Sarojini, Ojeda Sergio R
Abstract excerpt
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MECP2 gene. In the absence of MeCP2, expression of FXYD domain-containing transport regulator 1 (FXYD1) is deregulated in the frontal cortex (FC) of mice and humans. Because Fxyd1 is a membrane protein that controls cell excitability by modulating Na+, K+-ATPase activity (NKA), an excess of Fxyd1 may reduce NKA activity and contribute...
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