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Article

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells.

Carcinogenesis - 1 Feb 2017

Khan Naghma, Jajeh Farah, Khan Mohammad Imran, Mukhtar Eiman, Shabana Sameh M, Mukhtar Hasan

Abstract excerpt

Many purified compounds from dietary sources have been investigated for their anticancer activities. The main issue with most agents is their effectiveness at high doses which generally could not be delivered to humans through dietary consumption. Here, we observed that cucurbitacin B, a tetracyclic triterpenoid present in pumpkins, gourds and squashes, exhibits antiproliferative effects on human non-small cell...

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Identifiers

PMID: 27881463
DOI: 10.1093/carcin/bgw124
PMCID: PMC6075515

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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