Article

Exploring acenocoumarol and silodosin as allosteric EGFR inhibitors for the treatment of non-small cell lung cancer

2024-11-21

Abstract excerpt

Background Non-small-cell lung cancer (NSCLC) is a highly morbid disease. Chemotherapy for NSCLC lacks specificity and efficacy mainly because of drug resistance. The current study aimed to explore computational tools to target allosteric epidermal growth factor receptor (EGFR) sites and screen for the top molecules in vitro and in vivo xenograft models. Methods Molecular docking, virtual screening, and molecula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af7ca634-eb3d-53cc-bbfb-3ca375d1c555
DOI: 10.12688/f1000research.157465.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring acenocoumarol and silodosin as allosteric EGFR inhibitors for the treatment of non-small cell lung cancerDOI 10.12688/f1000research.157465.1Read

Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanismsSemantic proximity Read

Design, synthesis and biological evaluation of potent epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors against resistance mutation for lung cancer treatment.Semantic proximity Read

Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth.Semantic proximity Read

A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer.Semantic proximity Read

Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles.Semantic proximity Read

Parthenolide inhibits the growth of non-small cell lung cancer by targeting epidermal growth factor receptorSemantic proximity Read

Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and ChallengesSemantic proximity Read

Tyrosine kinase inhibitors - small molecular weight compounds inhibiting EGFR.Semantic proximity Read

Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites.Semantic proximity Read

Design and synthesis of novel EGFR kinase inhibitors for the treatment of EGFR C797S mutation in non-small cell lung cancerSemantic proximity Read

EGFR antagonists in cancer treatment.Semantic proximity Read

Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019).Semantic proximity Read