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Analysis of the Contribution of cyp51 Genes to Azole Resistance in Aspergillus Section Nigri with the CRISPR-Cas9 Technique

9 Mar 2021

Abstract excerpt

Cyp51 contribution to azole resistance has been broadly studied and characterized in Aspergillus fumigatus , whereas it remains poorly investigated in other clinically relevant species of the genus, such as those of section Nigri . In this work, we aimed to analyze the impact of cyp51 genes ( cyp51A and cyp51B ) on the voriconazole (VRC) response and resistance of Aspergillus niger and Aspergillus tubingensis .

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PMID: 33685892
DOI: 10.1128/aac.01996-20

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