Article

Leveraging primate-specific genomic information for genetic studies of complex diseases

2022-12-21

Abstract excerpt

<title>Abstract</title> <p>Genomic changes specific to higher primates are regarded as primate-specific genomic information (PSI). Using PSI to inform genetic studies is highly desirable but hampered by three factors: heterogeneity among PSI studies, lack of integrated profiles of the identified PSI elements and dearth of relevant functional information. We report a database of 19,767 PSI elements collated from n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d13f8d4c-5d02-5d54-9f04-b776267776b9
DOI: 10.21203/rs.3.rs-2368662/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging primate-specific genomic information for genetic studies of complex diseasesDOI 10.21203/rs.3.rs-2368662/v1Read

Structurally divergent and recurrently mutated regions of primate genomesSemantic proximity Read

Current advances in primate genomics: novel approaches for understanding evolution and disease.Semantic proximity Read

Analysis of genomic loci harboring 59,732 human-specific regulatory sequences reveals unique to human regulatory patterns associated with brain developmentSemantic proximity Read

High-resolution comparative analysis of great ape genomes.Semantic proximity Read

Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory FunctionsSemantic proximity Read

A global catalog of whole-genome diversity from 233 primate speciesSemantic proximity Read

Human Genomics. Sleeping dogs of the genome.Semantic proximity Read

Human-lineage-specific genomic elements: relevance to neurodegenerative disease and <i>APOE</i> transcript usageSemantic proximity Read

A single-cell multi-omic atlas spanning the adult rhesus macaque brainSemantic proximity Read

Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomicsSemantic proximity Read

Resources for functional genomic studies of health and development in nonhuman primates.Semantic proximity Read

Graph pangenome reveals functional, evolutionary, and phenotypic significance of human nonreference sequencesSemantic proximity Read