Article
Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.
Frontiers in immunology - 1 Jan 2018
Cooles Faye A H, Anderson Amy E, Skelton Andrew, Pratt Arthur G, Kurowska-Stolarska Mariola S, McInnes Iain, Hilkens Catharien M U, Isaacs John D
Abstract excerpt
Objective: Dendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs. In contrast, CD141+ DCs and plasmacytoid DCs (pDCs) have not been systematically examined, at least in early RA. In established RA, the role of pDCs is ambiguous and, since disease duration and treatment both impact RA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.