Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis.

doi:10.1038/ng0695-196

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Article

Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis.

Nature genetics - 1 Jun 1995

Christofori G, Naik P, Hanahan D

Abstract excerpt

In a mouse model of multistage carcinogenesis elicited by the SV40 large T-antigen (Tag) oncogene in pancreatic beta cells, the gene for insulin-like growth factor IGF2 is focally up-regulated and functionally implicated in tumour development. The IGF2 gene is differentially regulated in normal t...

Topics

Alleles
Animals
Base Sequence
Cell Transformation, Neoplastic
Gene Expression Regulation, Neoplastic
Genomic Imprinting
Genotype
Insulin-Like Growth Factor II
Islets of Langerhans
Mice
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
Molecular Sequence Data
Muscle Proteins
Pancreatic Neoplasms
Phenotype
RNA, Long Noncoding

Source

Open in PubMed

Identifiers

PMID: 7663515
DOI: 10.1038/ng0695-196

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7663515-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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