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Article

The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

1 Jun 2018

Abstract excerpt

INTRODUCTION: We examined expression of genes in the p53-signaling pathway. We determine if genes that have significantly different expression in carcinoma tissue compared to normal mucosa also have significantly differentially expressed miRNAs. We utilize a sample of 217 CRC cases. METHODS: We focused on fold change (FC) > 1.50 or <0.67 for genes and miRNAs, that were statistically significant after adjustment...

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PMID: 29860032
DOI: 10.1016/j.ygeno.2018.05.006

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