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Classical swine fever virus genotype 2.1 triggers stronger inflammatory and immune responses in porcine alveolar macrophages than genotype 3.4.

Developmental and comparative immunology - 1 Nov 2025

Huang Yu-Chun, Deng Ming-Chung, Huang Yu-Liang, Tsai Kuo-Jung, Liu Hsin-Meng, Liu I-Li, Lin Chen-Si, Chang Chia-Yi

Abstract excerpt

Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is a highly contagious disease characterized by immunosuppression. Since 1996, a shift from CSFV genotype 3.4 (G3.4) to genotype 2.1 (G2.1) has been observed in Taiwan. Although G2.1 exhibits higher replication efficiency than G3.4, their differential immune regulatory mechanisms remain unclear. This study investigated the responses of...

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PMID: 41115599
DOI: 10.1016/j.dci.2025.105496

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TNF

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