Article
Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis.
The Journal of rheumatology - 1 Aug 2018
Guderud Kari, Mæhlen Marthe Thoresen, Nordang Gry Beate Namløs, Viken Marte Kathrine, Andreassen Bettina Kulle, Molberg Øyvind, Flåm Siri Tennebø, Lie Benedicte Alexandra
Abstract excerpt
OBJECTIVE: We aimed to jointly investigate the role of antipeptidyl arginine deiminase type 4 antibodies (anti-PAD4) and polymorphisms in the PADI4 gene together with clinical variables in rheumatoid arthritis (RA). METHODS: Serum IgG autoantibodies to human recombinant PAD4 were identified by DELFIA technique in 745 patients with RA (366 available from previous studies). Genotyping of PADI4 was performed using...
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