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Article

Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast.

PloS one - 1 Jan 2018

Yang Yikun, Liu Qiannan, Jiang Guanglie, Chen Si, Zhou Lina, Sakamoto Norihiro, Kuno Takayoshi, Fang Yue, Yao Fan

Abstract excerpt

To study sodium homeostasis, we performed a genome-wide screen for deletion strains that show resistance to NaCl. We identified 34 NaCl-resistant strains. Among them, the largest group that consists of 10 genes related to membrane trafficking and 7 out of 10 genes are ESCRT proteins which are involved in cargo transportation into luminal vesicles within the multivesicular body. All of the ESCRT related mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29856841
DOI: 10.1371/journal.pone.0198516
PMCID: PMC5983419

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