An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.

doi:10.1007/s00125-018-4640-0

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An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.

Diabetologia - 1 Aug 2018

Graae Anne-Sofie, Hollensted Mette, Kloppenborg Julie T, Mahendran Yuvaraj, Schnurr Theresia M, Appel Emil Vincent R, Rask Johanne, Nielsen Tenna R H, Johansen Mia Ø, Linneberg Allan, Jørgensen Marit E, Grarup Niels, Kadarmideen Haja N, Holst Birgitte, Pedersen Oluf, Holm Jens-Christian, Hansen Torben

Abstract excerpt

AIMS/HYPOTHESIS: A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS53) was recently demonstrated to associate with insulin resistance in adults. We speculated that the GRS53 might already associate with insulin resistance during childhood, and we therefore aimed to investigate this in populations of Danish children and adolescents. Furthermore, we aimed to address whether the GRS...

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PMID: 29855666
DOI: 10.1007/s00125-018-4640-0
PMCID: PMC6061152

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