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Article

Analysis of Genetic Variation Indicates DNA Shape Involvement in Purifying Selection.

Molecular biology and evolution - 1 Aug 2018

Wang Xiaofei, Zhou Tianyin, Wunderlich Zeba, Maurano Matthew T, DePace Angela H, Nuzhdin Sergey V, Rohs Remo

Abstract excerpt

Noncoding DNA sequences, which play various roles in gene expression and regulation, are under evolutionary pressure. Gene regulation requires specific protein-DNA binding events, and our previous studies showed that both DNA sequence and shape readout are employed by transcription factors (TFs) to achieve DNA binding specificity. By investigating the shape-disrupting properties of single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29850830
DOI: 10.1093/molbev/msy099
PMCID: PMC6063282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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