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Article

TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells.

Oncotarget - 11 Apr 2017

Ratz Leonie, Laible Mark, Kacprzyk Lukasz A, Wittig-Blaich Stephanie M, Tolstov Yanis, Duensing Stefan, Altevogt Peter, Klauck Sabine M, Sültmann Holger

Abstract excerpt

TMPRSS2:ERG (T/E) gene fusions are present in approximately 50% of all prostate cancer (PCa) cases. The expression of fusion mRNAs from distinct T/E variants is associated with clinicopathological parameters, while the underlying molecular processes remain unclear. We characterized the molecular mechanisms and functional implications caused by doxycycline (Dox)-inducible overexpression of the frequent T/E III and...

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Share to Activin Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Oncogene Proteins, Fusion

Share to p38 Mitogen-Activated Protein Kinases

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Share to Smad7 Protein

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 28445989
DOI: 10.18632/oncotarget.15931
PMCID: PMC5421914

Genes

ERG
MMP1
TMPRSS2
VIM
CDH1
CDH2
SMAD7
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells.PMID 28445989Read ↗

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signalingSemantic proximity Read ↗

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer modelsSemantic proximity Read ↗

<i>TMPRSS2:ETV4</i> Gene Fusions Define a Third Molecular Subtype of Prostate CancerSemantic proximity Read ↗

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.Semantic proximity Read ↗

Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.Semantic proximity Read ↗

ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cellsSemantic proximity Read ↗

Pleiotropic Biological Activities of Alternatively Spliced TMPRSS2/ERG Fusion Gene TranscriptsSemantic proximity Read ↗

The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate CancerSemantic proximity Read ↗

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation–Mass Spectrometry AssaysSemantic proximity Read ↗

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein with Orthogonal Immunoprecipitation-Mass Spectrometry AssaysSemantic proximity Read ↗

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumorsSemantic proximity Read ↗

Role of Epithelial Mesenchymal Transition in Prostate TumorigenesisSemantic proximity Read ↗

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