Article
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2007
Meireles Ana Margarida, Preto Ana, Rocha Ana Sofia, Rebocho Ana Paula, Máximo Valdemar, Pereira-Castro Isabel, Moreira Severina, Feijão Tália, Botelho Tiago, Marques Ricardo, Trovisco Vítor, Cirnes Luís, Alves Cíntia, Velho Sérgia, Soares Paula, Sobrinho-Simões Manuel
Abstract excerpt
OBJECTIVE: Our aim was to characterize the molecular and genotypic profile of eight thyroid carcinoma-derived cell lines-TPC1, FB2, B-CPAP, K1, XTC-1, C643, 8505C, and Hth74-in order to use them as in vitro models of thyroid carcinogenesis. DESIGN: We evaluated the expression of five thyroid-specific genes (Tg, TSHr, TPO, PAX8, and TTF-1) to establish the cell lineage and to assess the differentiation status of...
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