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Article

Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation.

Molecular cancer research : MCR - 1 Aug 2020

Dasari Subramanyam, Pandhiri Taruni, Grassi Tommaso, Visscher Daniel W, Multinu Francesco, Agarwal Komal, Mariani Andrea, Shridhar Viji, Mitra Anirban K

Abstract excerpt

Treatment of ovarian cancer is limited by extensive metastasis and yet it remains poorly understood. We have studied the critical step of metastatic colonization in the context of the productive interactions with the metastatic microenvironment with a goal of identifying key regulators. By combining miRNA expression analysis using an organotypic 3D culture model of early ovarian cancer metastasis with that of...

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Identifiers

PMID: 32350057
DOI: 10.1158/1541-7786.MCR-19-1162
PMCID: PMC10788085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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