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Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer's-like clinical phenotype.

Alzheimer's research & therapy - 21 May 2024

Lorenzini Luca, Zanella Lorenzo, Sannia Michele, Baldassarro Vito Antonio, Moretti Marzia, Cescatti Maura, Quadalti Corinne, Baldi Simone, Bartolucci Gianluca, Di Gloria Leandro, Ramazzotti Matteo, Clavenzani Paolo, Costanzini Anna, De Giorgio Roberto, Amedei Amedeo, Calzà Laura, Giardino Luciana

Abstract excerpt

Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer's disease (AD), as supported by epidemiological and preclinical data, and several epidemiological studies indicate a higher prevalence of AD in patients with inflammatory bowel disease. In this study, we explored whether colitis induced by dextran sulfate sodium (DSS) in young, presymptomatic/preplaque mice...

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Identifiers

PMID: 38773640
DOI: 10.1186/s13195-024-01471-2
PMCID: PMC11110243

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