Article
Intrinsic Activity of C57BL/6 Substrains Associates with High-Fat Diet-Induced Mechanical Sensitivity in Mice.
The journal of pain - 1 Nov 2018
Cooper Michael A, O'Meara Bryn, Jack Megan M, Elliot Dan, Lamb Bradley, Khan Zair W, Menta Blaise W, Ryals Janelle M, Winter Michelle K, Wright Douglas E
Abstract excerpt
Pain is significantly impacted by the increasing epidemic of obesity and the metabolic syndrome. Our understanding of how these features impact pain is only beginning to be developed. Herein, we have investigated how small genetic differences among C57BL/6 mice from 2 different commercial vendors lead to important differences in the development of high-fat diet-induced mechanical sensitivity. Two substrains of...
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