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Article

A combination of genetics and microbiota influences the severity of the obesity phenotype in diet-induced obesity.

Scientific reports - 9 Apr 2020

Smoczek Margarethe, Vital Marius, Wedekind Dirk, Basic Marijana, Zschemisch Nils-Holger, Pieper Dietmar H, Siebert Anja, Bleich Andre, Buettner Manuela

Abstract excerpt

Obesity has emerged as a major global health problem and is associated with various diseases, such as metabolic syndrome, type 2 diabetes mellitus, and cardiovascular diseases. The inbred C57BL/6 mouse strain is often used for various experimental investigations, such as metabolic research. However, over time, genetically distinguishable C57BL/6 substrains have evolved. The manifestation of genetic alterations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32273571
DOI: 10.1038/s41598-020-63340-w
PMCID: PMC7145845

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