Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders.

ACS combinatorial science - 9 Jul 2018

Kruziki Max A, Sarma Vidur, Hackel Benjamin J

Abstract excerpt

Engineered protein ligands are used for molecular therapy, diagnostics, and industrial biotechnology. The Gp2 domain is a 45-amino acid scaffold that has been evolved for specific, high-affinity binding to multiple targets by diversification of two solvent-exposed loops. Inspired by sitewise enrichment of select amino acids, including cysteine pairs, in earlier Gp2 discovery campaigns, we hypothesized that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Combinatorial Chemistry Techniques
Share to Disulfides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to Ligands

Share to Peptide Library

Share to Protein Engineering

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 29799714
DOI: 10.1021/acscombsci.8b00010
PMCID: PMC6051759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders.PMID 29799714Read ↗

Engineered Charge Redistribution of Gp2 Proteins through Guided Diversity for Improved PET Imaging of Epidermal Growth Factor Receptor.Semantic proximity Read ↗

A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering.Semantic proximity Read ↗

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discoverySemantic proximity Read ↗

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.Semantic proximity Read ↗

Ribosome Display: A Potent Display Technology used for Selecting and Evolving Specific Binders with Desired PropertiesSemantic proximity Read ↗

DexDesign: A new OSPREY-based algorithm for designing <i>de novo</i> D-peptide inhibitorsSemantic proximity Read ↗

AXL-Receptor Targeted 14FN3 Based Single Domain Proteins (Pronectins™) from 3 Synthetic Human Libraries as Components for Exploring Novel Bispecific Constructs against Solid TumorsSemantic proximity Read ↗

High-throughput protein binder discovery by rapid in vivo selectionSemantic proximity Read ↗

Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential.Semantic proximity Read ↗

Selection of a PD ‐1 blocking antibody from a novel fully human phage display librarySemantic proximity Read ↗

Traversing through the Dynamic Protein–Protein Interaction Landscape and Conformational Plasticity of PD-1 for Small-Molecule DiscoverySemantic proximity Read ↗

Virtual Screening and In Vitro Evaluation of PD-1 Dimer Stabilizers for Uncoupling PD-1/PD-L1 Interaction from Natural Products.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.