Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer

22 May 2018

Abstract excerpt

Aberrant activation of Wnt/β-catenin signalling is critical in the progression of human cancers, especially colorectal cancer (CRC). Therefore, inhibition of Wnt/β-catenin signalling is a significant potential target for CRC therapy. Here, we identified for the first time that Physalin F (PF), a steroid derivative isolated from Physalis angulate, acts as an antagonist of Wnt/β-catenin signalling. In vitro, PF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genital Health and Disease
Share to Hippo pathway signaling and YAP/TAZ
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29789528
DOI: 10.1038/s41419-018-0645-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancerPMID 29789528Read ↗

Targeting Wnt/β-Catenin Pathway for Drug TherapySemantic proximity Read ↗

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer TherapeuticsSemantic proximity Read ↗

Modulation of Wnt/ -catenin signaling pathway by bioactive food componentsSemantic proximity Read ↗

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer.Semantic proximity Read ↗

Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancerSemantic proximity Read ↗

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.Semantic proximity Read ↗

Wnt signaling as a therapeutic target for cancer.Semantic proximity Read ↗

Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen.Semantic proximity Read ↗

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βSemantic proximity Read ↗

Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interactionSemantic proximity Read ↗

Wnt/?-catenin-pathway as a molecular target for future anti-cancer therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.