Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation.

Abstract excerpt

Abnormal platelet membrane fluidity was found in a 50-year-old woman with Down syndrome who had been experiencing a gradual mental decline. The patient's karyotype showed a triplication of the long arm of chromosome 21. The authors hypothesize that the PMF-locus, which carries the allele for increased membrane fluidity, is located on the long arm of chromosome 21. Similarities between Down syndrome and...

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