Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation.

doi:10.1177/089198878800100406

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Article

Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation.

Journal of geriatric psychiatry and neurology - 1 Jan 2000

Zubenko G S, Howland R

Abstract excerpt

Abnormal platelet membrane fluidity was found in a 50-year-old woman with Down syndrome who had been experiencing a gradual mental decline. The patient's karyotype showed a triplication of the long arm of chromosome 21. The authors hypothesize that the PMF-locus, which carries the allele for incr...

Topics

Alzheimer Disease
Blood Platelets
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Down Syndrome
Female
Humans
Karyotyping
Membrane Fluidity
Middle Aged
Phenotype
Translocation, Genetic

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