Article
Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis.
Gene - 20 Aug 2018
Feng Yuan, Hong Yaqiang, Zhang Xin, Cao Chunwei, Yang Xichao, Lai Shujuan, Fan Chunmei, Cheng Feng, Yan Mei, Li Chaohua, Huang Wan, Chen Wei, Zhu Ping, Zeng Changqing
Abstract excerpt
Although ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the precise genetic mechanism underlying the disease remains elusive. Here, we investigate the disease-causing mutations in a large AS family with distinguished complexity, consisting of 23 patients covering four generations and exhibiting a mixed HLA-B27 (+) and (-) status. Linkage analysis with 32 members using three methods and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.