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Article

BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors.

Pigment cell & melanoma research - 1 Nov 2018

Doxie Deon B, Greenplate Allison R, Gandelman Jocelyn S, Diggins Kirsten E, Roe Caroline E, Dahlman Kimberly B, Sosman Jeffrey A, Kelley Mark C, Irish Jonathan M

Abstract excerpt

Little is known about the in vivo impacts of targeted therapy on melanoma cell abundance and protein expression. Here, 21 antibodies were added to an established melanoma mass cytometry panel to measure 32 cellular features, distinguish malignant cells, and characterize dabrafenib and trametinib responses in BRAFV600mut melanoma. Tumor cells were biopsied before neoadjuvant therapy and compared to cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29778085
DOI: 10.1111/pcmr.12712
PMCID: PMC6188784

Genes

SOX10
BRAF
NES
SOX2

Provenance

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